Month: January 2023

Synthesis and anti-platelet aggregation activity evaluation of ligustrazine H₂S donor derivatives was written by Luo, Bi-lan;Liu, Zi-bing;Li, Yi;Zhao, Ju-qin;Li, Yong;Zhang, Yi;Tang, Lei;Fan, Ling-ling. And the article was included in Huaxue Shiji in 2020.Application of 628-13-7 This article mentions the following:

Based on the principles of the combination and bioisosterism, three ligustrazine H₂S donor derivatives were designed and synthesized by substitution, cyclation, oxidation, esterification and etherification reactions using 4-hydroxyacetophenone and ligustrazine as the starting materials. The structures were confirmed by ¹HNMR, ¹³CNMR and HR-MS. The in vitro anti-platelet aggregation activities of the target compounds have been preliminarily tested by the Born turbidimetric method, and the exptl. results showed that 4-(3-thioxo-3H-1, 2-dithiol-5-yl) phenyl-3,5,6-trimethylpyrazine-2-carboxylate shown in I (IC₅₀=1.16 mmol/L) had significant inhibitory activity for ADP induced platelet aggregation, which was better than clin. drugs ligustrazine, 3-n-butylphthalide, edaravone and aspirin. Therefore, it may be used as a potential candidate for the treatment of cardiovascular and cerebrovascular disease. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine-directed carbon-carbon single bond activation: Rhodium-catalyzed decarbonylation of aryl and heteroaromatic ketones was written by Wagner, Cole J.;Salisbury, Eric A.;Schoonover, Erik J.;VanderRoest, Jacob P.;Johnson, Jeffrey B.. And the article was included in Tetrahedron Letters in 2021.Category: pyridine-derivatives This article mentions the following:

The decarbonylation of 2-pyridyl-substituted ketones via transition metal-catalyzed carbon-carbon bond activation provided ready access to a variety of biaryl compounds The highly efficient and general method provided reliable decarbonylation of benzophenones including a range of functional groups and substitution patterns. The methodol. has also proven highly efficient for heteroaromatic substrates, including those containing thiophenyl, indolyl, quinolinyl and pyridine substitution. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt′;s Lymphoma was written by Byrne, Andrew J.;Bright, Sandra A.;Fayne, Darren;McKeown, James P.;McCabe, Thomas;Twamley, Brendan;Williams, Clive;Meegan, Mary J.. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2018.Application In Synthesis of Pyridinehydrochloride This article mentions the following:

Background: Cancers of the lymphatic cells (lymphomas) account for approx. 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt′s lymphoma (BL). Objectives: The aims of the curent study were to synthesize a panel of nitrostyrene compounds and to evaluate their activity in Burkitt′s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesized using Henry Knoevenagel condensation reactions. Single crystal X-Ray anal. confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG- 75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, resp., in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt′s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt′s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acyl-2,3-dihydropyridones was written by Guzel, Mustafa;Watts, Joshua;McGilvary, Matthew;Wright, Marcus;Kiren, Sezgin. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 24103-75-1 This article mentions the following:

A general and efficient synthetic approach toward substituted pyridines from functionalized N-acyl-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil is described. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Recommanded Product: 24103-75-1).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 24103-75-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, characterization, antimicrobial and interaction studies of pteridines with human serum albumin: A combined multi-spectroscopic and computational study was written by Raghu, M. S.;Kumar, K. Yogesh;Veena, K.;Kumar, C. B. Pradeep;Almalki, Amani Salem;Mani, G.;Alasmary, Fatmah Ali;Prashanth, M. K.. And the article was included in Journal of Molecular Structure in 2022.Computed Properties of C12H9NO This article mentions the following:

A novel series of pteridine derivatives I [R = H, F, Cl, F₃C, Br] was synthesized, and the structures of these mols. were established using elemental anal. and numerous spectroscopic methods. The disk diffusion technique was used to examine the antimicrobial potential of the newly synthesized mols. Among the compounds examined, I [R = F, F₃C] compounds had the highest impact against the examined bacterial and fungal strains. The compounds min. inhibitory concentration (MIC) was observed to be in the line of 0.41-6.83μM. UV-vis absorption, fluorescence quenching, FT-IR spectroscopy and CD (CD) along with mol. docking methods, were studies to assess the binding behavior of efficient pteridine derivatives I [R = F, F₃C] with human serum albumin (HSA). Formation of HSA-test compounds complex indicated the static quenching phenomena during fluorescence quenching of HSA by test compounds Synthesized I [R = F, F₃C] were further evaluated for three basic binding sites of HSA including subdomains IIA, IIIA, and IB, using mol. docking studies. Hydrophobic and interaction through hydrogen bonding influenced the binding pathway of HSA with test mols., according to the mol. docking data. Furthermore, the DFT technique was used to optimize the mol. geometry of potent I [R = F, F₃C] compounds using the B3LYP hybrid functional and the 6-311 + G(d, p) basis set. The optimized structure closely aligned with the test findings. The electrostatic potential framework was produced to visualize the mol.’s energy distribution and chem. reactive areas. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Computed Properties of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats was written by Litchfield, John;Sharma, Raman;Atkinson, Karen;Filipski, Kevin J.;Wright, Stephen W.;Pfefferkorn, Jeffrey A.;Tan, Beijing;Kosa, Rachel E.;Stevens, Benjamin;Tu, Meihua;Kalgutkar, Amit S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 343262-51-1 This article mentions the following:

Previous studies on the in vitro metabolism of 4-alkylsulfonyl-2-pyridone-based glucokinase activators revealed a facile, non-enzymic displacement of the 4-alkylsulfonyl group by glutathione. In the present studies, a role for glutathione-S-transferases (GST) as catalysts in the desulfonylation reaction was demonstrated using a combination of human liver microsomes, human liver cytosol and human GSTs. The identification of a glutathione conjugate in circulation following i.v. administration of a candidate 4-methylsulfonyl-2-pyridone to rats confirmed the relevance of the in vitro findings. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1HPLC of Formula: 343262-51-1).

2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 343262-51-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel benzothiophene H₁-antihistamines for the treatment of insomnia was written by Moree, Wilna J.;Jovic, Florence;Coon, Timothy;Yu, Jinghua;Li, Bin-Feng;Tucci, Fabio C.;Marinkovic, Dragan;Gross, Raymond S.;Malany, Siobhan;Bradbury, Margaret J.;Hernandez, Lisa M.;O’Brien, Zhihong;Wen, Jianyun;Wang, Hua;Hoare, Samuel R. J.;Petroski, Robert E.;Sacaan, Aida;Madan, Ajay;Crowe, Paul D.;Beaton, Graham. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C6H3FN2 This article mentions the following:

SAR of lead benzothiophene H₁-antihistamine I (R = 2-pyridyl) was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H₁-antihistamines with a range of projected half-lives in humans were identified. Had a suitable human half-life as demonstrated in a human microdose study, but variability in pharmacokinetic profile, attributed to metabolic clearance, prevented further development of this compound I (R = 1-pyrazolyl) demonstrated lower predicted clearance in preclin. studies, and may represent a more suitable backup compound In the experiment, the researchers used many compounds, for example, 6-Fluoropicolinonitrile (cas: 3939-15-9Synthetic Route of C6H3FN2).

6-Fluoropicolinonitrile (cas: 3939-15-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Micellar Effects of Cationic Detergents in the Decomposition of Ecotoxic Substrates by Hydroxide Ion was written by Simanenko, Yu. S.;Popov, A. F.;Prokop’eva, T. M.;Karpichev, E. A.;Belousova, I. A.;Savelova, V. A.. And the article was included in Theoretical and Experimental Chemistry (Translation of Teoreticheskaya i Eksperimental’naya Khimiya) in 2003.Product Details of 104-73-4 This article mentions the following:

The rate of decomposition of 4-nitrophenyl esters of diethylphosphoric, diethylphosphonic, and 4-toluenesulfonic acids, which are ecotoxicants, by hydroxide ion is enhanced by micelles of cationic detergents. The effect of concentrating the reagents provides for decomposition of the neurotoxins in aqueous micellar media with τ_1/2 ≤ 60 s. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Product Details of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of 3-pyridylpropenoic acid esters via Heck coupling of substituted 3-pyridyl triflates was written by Draper, Tandy L.;Bailey, Thomas R.. And the article was included in Synlett in 1995.Related Products of 15128-90-2 This article mentions the following:

From com. available 3-hydroxypyridines, several 3-pyridinepropenoic Et esters were prepared in good yield via Heck coupling of Et acrylate and the pyridyl triflate. In general, LiCl accelerated the coupling, but was not required for all reactions. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Related Products of 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

First Cu^II Diamondoid Net with 2-Fold Interpenetrating Frameworks. The Role of Anions in the Construction of the Supramolecular Arrays was written by Du, Miao;Bu, Xian-He;Guo, Ya-Mei;Liu, He;Batten, Stuart R.;Ribas, Joan;Mak, Thomas C. W.. And the article was included in Inorganic Chemistry in 2002.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

The synthesis and crystal structure of the three-dimensional coordination polymer of an angular dipyridyl ligand 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (L) and Cu(ClO₄)₂, exhibiting the 1st Cu^II diamondoid network with 2-fold interpenetration, {[Cu(L)₂(H₂O)₂](ClO₄)(OH)(H₂O)_2.5}_n (1), together with the Cu(OAc)₂ complex of L, [Cu(L)₂(OAc)₂(H₂O)](H₂O)₂(MeOH) (2), with an unexpected mononuclear structure, are reported. Crystal data for 1: tetragonal, space group I4₁/a, a = b 13.477(3), c 46.167(13) Å, Z = 8. Crystal data for 2: triclinic, space group P1̅, a 7.847(2), b 13.189(4), c 15.948(5) Å, α 75.225(7), β 79.945(6), γ 77.540(5)°, Z = 2. The magnetic properties and anion effect are also discussed. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem