Day: February 13, 2023

4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors was written by Hondo, Takeshi;Warizaya, Masaichi;Niimi, Tatsuya;Namatame, Ichiji;Yamaguchi, Tomohiko;Nakanishi, Keita;Hamajima, Toshihiro;Harada, Katsuya;Sakashita, Hitoshi;Matsumoto, Yuzo;Orita, Masaya;Takeuchi, Makoto. And the article was included in Journal of Medicinal Chemistry in 2013.HPLC of Formula: 34206-49-0 This article mentions the following:

4-Hydroxypyridazin-3(2H)-ones such as I [R = Ph, PhCH₂, cyclohexylmethyl, 4-ClC₆H₄, Me₃C, 2-FC₆H₄, 2-F₃CC₆H₄, 3-FC₆H₄, 3-F₃CC₆H₄, 3-MeOC₆H₄, 4-FC₆H₄, 4-F₃CC₆H₄, 4-MeOC₆H₄, 3,4-F₂C₆H₃, 3,5-(F₃C)₂C₆H₃, 3,5-(MeO)₂C₆H₃; X = N] were prepared as inhibitors of human D-amino acid oxidase (hDAAO) for potential use as treatments for schizophrenia based on the binding of smaller fragments such as benzoic acid and 3-hydroxy-2-pyridinone to hDAAO. Based on the crystal structure of the complex of 3-hydroxy-2-pyridinone and hDAAO, compounds such as I (R = Ph; X = CH) with the ability to fill an adjacent ligand-dependent binding pocket of hDAAO were designed and prepared; I (R = Ph; X = CH) inhibited hDAAO with IC₅₀ values of 3.9 nM and 20 nM in enzyme- and cell-based assays, resp. but was toxic at high concentrations Pyridazinone analogs of I (R = Ph; X = CH) were prepared as analogs with potentially reduced toxicities. In particular, I (R = 3,5-F₂C₆H₃; X = N) inhibited DAAO in vitro, and in human, rat, and murine cells with IC₅₀ values of 1.5-16 nM, entered the brains of mice within 30 min after oral dosage (brain concentration = 460 ng/mL), and improved cognitive function in a mouse model of schizophrenia. The structures of I (R = Ph; X = CH, N) and of 3-hydroxy-2-pyridinone bound to hDAAO were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 5-Bromopyridine-2,3-diol (cas: 34206-49-0HPLC of Formula: 34206-49-0).

5-Bromopyridine-2,3-diol (cas: 34206-49-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 34206-49-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents was written by Andersen, Claire;Ferey, Vincent;Daumas, Marc;Bernardelli, Patrick;Guerinot, Amandine;Cossy, Janine. And the article was included in Organic Letters in 2020.Computed Properties of C10H17NO2 This article mentions the following:

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyliodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides was written by Morisawa, Yasuhiro;Kataoka, Mitsuru;Sakamoto, Toshiaki;Nagahori, Hitoshi;Kitano, Noritoshi;Kusano, Kenichi. And the article was included in Journal of Medicinal Chemistry in 1978.Product Details of 65169-38-2 This article mentions the following:

Twelve methyl-2-nitro- and 9 methyl-3-nitropyridinecarboxamides were prepared and tested in vivo for anticoccidial activity against Eimeria鑱?em>tenella. Almost all the compounds were active, with optimal activity shown by 5-methyl- (I) [65169-65-5] and 6-methyl-2-nitroisonicotinamide (II) [60780-18-9], which were as potent as 2-nitroisonicotinamide. At least 1 H atom adjacent to the NO₂ group is important for anticoccidial activity and a Me group adjacent to the CONH₂ function sometimes enhances activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Product Details of 65169-38-2).

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 65169-38-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective dimerization of 1-butene in biphasic mode using buffered chloroaluminate ionic liquid solvents – design and application of a continuous loop reactor was written by Wasserscheid, P.;Eichmann, M.. And the article was included in Catalysis Today in 2001.Formula: C10H16ClN This article mentions the following:

The dimerization of 1-butene using (cod)Ni(hfacac) 1 as catalyst has been investigated in different chloroaluminate ionic liquids Systems prepared by buffering an acidic ionic liquid with weak organic bases proved to be very suitable solvents for the reaction. The reaction takes place in biphasic reaction mode with facile catalyst separation and catalyst recycling. The high intrinsic dimer linearity of catalyst 1 is maintained, but with significant enhancement of catalyst activity and of the selectivity to the dimer product over that observed in toluene solvent. For further investigation, a continuous reactor was designed. Our results in continuous mode show the general tech. applicability of the selective Ni-catalyzed dimerization in chloroaluminate ionic liquids using a loop reactor concept. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Formula: C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ru(II)-Catalyzed Direct C(sp²)-H Activation/Selenylation of Arenes with Selenyl Chlorides was written by Shu, Shiqi;Fan, Zhoulong;Yao, Qizheng;Zhang, Ao. And the article was included in Journal of Organic Chemistry in 2016.Name: 2-(m-Tolyl)pyridine This article mentions the following:

A new ruthenium catalytic system was developed for the construction of a C(sp²)-Se bond with the assistance of directing groups. This protocol features mild reaction conditions, wider substrate scope, and convenient late-stage selenylation of bioactive mols. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hydroarylation of Arenes via Reductive Radical-Polar Crossover was written by Flynn, Autumn R.;McDaniel, Kelly A.;Hughes, Meredith E.;Vogt, David B.;Jui, Nathan T.. And the article was included in Journal of the American Chemical Society in 2020.Name: tert-Butyl (3-bromopyridin-4-yl)carbamate This article mentions the following:

A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective radical cyclization event, followed by anion formation and quenching to produce a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aqueous MeCN) without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Name: tert-Butyl (3-bromopyridin-4-yl)carbamate).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: tert-Butyl (3-bromopyridin-4-yl)carbamate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinetics of methyl chloroformate ethanolysis in presence of pyridine 1-oxides was written by Grabarnik, M. S.;Chimishkyan, A. L.;Orlov, S. I.;Burmistrov, S. Yu.. And the article was included in Organic Reactivity (Tartu) in 1990.Recommanded Product: 3718-65-8 This article mentions the following:

A kinetic study of ClCO₂Me ethanolysis in the presence of pyridine 1-oxides was interpreted in terms of general base and nucleophilic catalysis. The effect of substituents in the pyridine ring was described by a Yukawa-Tsuno equation. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Recommanded Product: 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Study on selectivity in the reaction of 2-substituted pyridinium-N-imines with dimethyl acetylenedicarboxylate was written by Supranovich, Vyacheslav I.;Vorob’ev, Aleksey Yu.;Borodkin, Gennady I.;Gatilov, Yury V.;Shubin, Vyacheslav G.. And the article was included in Tetrahedron Letters in 2016.Application In Synthesis of 2-Phenoxypyridine This article mentions the following:

Reactions of 2-X-pyridinium-N-imines (X = F, Cl, Br, CN, OPh, NH₂, N-morpholine) with di-Me acetylenedicarboxylate (DMAD) were studied. In the case of X = Cl, Br, CN, OPh both 7-substituted- and 7-H-pyrazolo[1,5-a]pyridines are formed. The 7-H/7-X ratio usually increases with the growing solvent polarity. The reaction of N-amino-2-iminopyridine with DMAD gives substituted pyrido[1,2-b][1,2,4]triazine. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application In Synthesis of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of a cerium(III) amide with heteroallenes: insertion, silyl-migration and de-insertion was written by Yin, Haolin;Carroll, Patrick J.;Schelter, Eric J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Synthetic Route of C5H6ClN This article mentions the following:

Reactions of Ce[N(SiMe₃)Ph^F]₃ (-Ph^F = pentafluorophenyl) toward small mols. of the type E₁=C=E₂ (E₁, E₂ = O, S, NR), including carbon disulfide, carbodiimide, carbon dioxide, isocyanate and isothiocyanate are reported, resulting in distinct products, including cerium(III) dithiocarbamate, cerium(III) guanidinate, isocyanates and unsym. carbodiimides. These reactions were rationalized as three consecutive stages of the same reaction pathway: insertion, silyl-migration and de-insertion. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem