Application of 56187-37-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56187-37-2, name is 2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetic acid. A new synthetic method of this compound is introduced below.
In a dry reaction flask, 137.66 g of 3,5-dichloro-4-pyridone-1-acetic acid (0.62 mol) and 222.64 gDibenzothiazyl disulfide (DM, 0.6696 mol) was dissolved in 500 mL of dichloromethane and 54 g (0.682 mol) of pyridine was added.The reaction was stirred at room temperature for 1 hour, and then an aqueous solution of triethyl phosphite (118.47 g of triethyl phosphite dissolved in 150 mL of methylene chloride, 0.713 mol) was added dropwise slowly.1-2 hours dropwise addition is complete, the reaction temperature was controlled at 20-25 C for 1-2 hours, filtered and the filtrate cooled down to below 10 C,Crystals were precipitated, suction filtered and dried to give 234.8 g of cefoxitin side chain acid active ester (0.6063 mol). The yield was 97.1% and the HPLC purity was 99.3%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56187-37-2, 2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetic acid, and friends who are interested can also refer to it.
Reference:
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Wang Jun; Zuo Cuiyong; Gao Feifei; (10 pag.)CN105017286; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem