Related Products of 26452-80-2 ,Some common heterocyclic compound, 26452-80-2, molecular formula is C5H3Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step B Preparation of 2,4-dichloro-3-pyridine Carboxaldehyde Under nitrogen, a solution of 1.6 g of 2,4-dichloropyridine in 5 mL dry tetrahydrofuran (THF) was added to a solution of 6 mL of lithium diisopropyl amide in 25 mL of THF at -70 C., followed by stirring at this temperature for 3 hours. Then 1 mL of dry N,N-dimethylformamide was added at -70 C. followed by stirring at this temperature for 1 hour. Then 25 mL of saturated ammonium chloride solution was added and the reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with 25 mL of water and extracted with ethyl acetate (2*). The combine organic phases were distilled under vacuum to give solids that were dissolved in 5 mL of methylene chloride and filtered through silica gel, eluding with 100% methylene chloride. Removal of the solvent under vacuum provided the title intermediate as a solid. 1H NMR (CDCl3; 300 MHz) delta7.41 (d, 1H, J is 5.3 Hz), 8.42 (d, 1H, J is 5.2 Hz), 10.5 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26452-80-2, its application will become more common.
Reference:
Patent; Neubert, Timothy Donald; Piotrowski, David Walter; Walker, Michael Paul; US2004/44040; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem