In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1380331-36-1, name is Ethyl 7-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate, the common compound, a new synthetic route is introduced below. Recommanded Product: 1380331-36-1
b) ethyl-7-(tert-butoxycarbonylamino)-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate To an argon purged solution of ethyl 7-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate (1.76 g, 6.52 mmol) in dioxane (45 ml) are added tert-butyl carbamate (916 mg, 7.82 mmol), tris(dibenzylideneacetone)dipalladium(0) (119 mg, 130 mumol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (151 mg, 261 mumol) and cesium carbonate (2.97 g, 9.12 mmol). The resulting mixture is heated to 110 C. and stirred for 20 hours. The reaction mixture is loaded on silica and purified by flash chromatography on a 50 g silica column using heptane/ethyl acetate 30-100% as eluent affording ethyl 7-(tert-butoxycarbonylamino)-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate (1.07 g, 54%) as a light yellow solid. mp.: 220-2 C. MS: m/z=307.3 (M+H+).
The synthetic route of 1380331-36-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Flohr, Alexander; Gobbi, Luca; Groebke Zbinden, Katrin; Koerner, Matthias; Peters, Jens-Uwe; US2012/142665; (2012); A1;,
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