Synthetic Route of 2587-02-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2587-02-2, name is 2,6-Dichloropyridin-4-amine, molecular formula is C5H4Cl2N2, molecular weight is 163.0047, as common compound, the synthetic route is as follows.
Intermediate 35 : 4-Chloro-6-methoxy-pyridine-2-carboxylic acid 35.1 : 2-Chloro-6-methoxy-pyridin-4-ylamine To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6- dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150 C for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried. yield: 5.00 g (79 %); ESI-MS: m/z = 159 (M+H)+; Rt(HPLC): 0.41 min (method 5)
Statistics shows that 2587-02-2 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloropyridin-4-amine.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd; WO2013/87805; (2013); A1;,
Pyridine – Wikipedia,
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