Application of 107504-07-4, Adding some certain compound to certain chemical reactions, such as: 107504-07-4, name is Methyl 5-fluoropicolinate,molecular formula is C7H6FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 107504-07-4.
To a mixture of (2,6-difluoro-4-iodophenyl)methanol (3 g) and THF (30 ml) was added sodium hydride (60% in oil, 444 mg) at 30C.The mixture was stirred at 30C for 30 min, and methyl 5-fluoropyridine-2-carboxylate (2.06 g) was added thereto. The mixture was stirred at 30C for 2 hr. To the mixture was added water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (2.4 g). 1H NMR (400 MHz, CDCl3) delta 3.98 (3H, s), 5.17 (2H, s), 7.30-7.45 (3H, m), 8.12 (1H, d, J = 8.8 Hz), 8.43 (1H, d, J = 2.8 Hz).
According to the analysis of related databases, 107504-07-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Takeda Pharmaceutical Company Limited; MIZOJIRI, Ryo; ASANO, Moriteru; TOMITA, Daisuke; BANNO, Hiroshi; TAWADA, Michiko; NII, Noriyuki; GIPSON, Krista E.; MAEZAKI, Hironobu; TSUCHIYA, Shuntaro; IMAI, Mayumi; AMANO, Yuichiro; (100 pag.)EP3279183; (2018); A1;,
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