Adding a certain compound to certain chemical reactions, such as: 97986-08-8, N,6-dimethylpyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 97986-08-8, blongs to pyridine-derivatives compound. Safety of N,6-dimethylpyridin-2-amine
Example 11N-[3,5-difmorpholin-4-yl)phenyll-N>-methyl-N>-f6-methylpyridin-2-yl)pyrimidine-2.,4- diamine4-Chloro-N-(3,5-dimorpholin-4-ylphenyl)pyrimidin-2-amine (described in Example 1, 200 mg, 0.53 mmol), 6-methyl-2-methylaminopyridine (98 mg, 0.8 mmol), potassium carbonate (736 mg, 5.3 mmol), Pd2dba3 (16 mg, 0.027 mmol) and Xantphos (31 mg, 0.053 mmol) were mixed in toluene (5 ml). The mixture was degassed with nitrogen and heated in a sealed tube at 1200C for 3 hours. After filtration, the toluene was evaporated and the residue purified on a preparative HPLC-MS system (Column: C18, 5 microns, 19 mm diameter, 100 mm length, elution with a gradient of water and acetonitrile containing 2g/l of ammonium carbonate) to give 55 mg of the title compound (22% yield). NMR Spectrum (500 MHz, DMSOd) 2.45 (s, 3H), 3.01 (m, 8H), 3.51 (s, 3H), 3.70 (m, 8H), 6.10 (s, IH), 6.30 (d, IH), 6.93 (d, 2H), 7.07 (d, IH), 7.23 (d, IH), 7.70 (t, IH), 8.00 (d, IH), 8.92 (s, IH). Mass Spectrum MH+ 462
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,97986-08-8, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/10794; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem