Electric Literature of 77555-27-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 77555-27-2, name is 2-(Pyridin-2-ylthio)ethanol. A new synthetic method of this compound is introduced below.
A solution of 0.2 g (0.55 mmol) of the product from example 11, Step C and 0.1 g (0.66 mmol) of the product from Example 23, step A in toluene (20 ml) was refluxed for 16 hours. The reaction mixture was partitioned between water and ethyl acetate. The combined organic layers were successively washed with water (25 ml x 2) and brine (25 ml x 2), dried over anhydrous sodium sulphate and evaporated under vacuo. The solid residue was purified by column chromatography over silica gel using 60 % ethyl acetate in hexane as the eluent to afford 0.1 g of the title compound as a yellow solid. ¹H NMR (400 MHz, DMSOd6) 8 3 – 3.11 (2H, t), 3.28 (2H, t), 3.55 – 3.56 (4H, t), 3.72 – 3.75 (4H, t), 6.92 – 6.95 (1H, d), 7.11 – 7.14 (1H, d), 7.35 – 7.37 (1H, d), 7.51 – 7.59 (3H, m), 7.62 – 7.67 (2H, m), 7.99 – 8.03 (3H, m), 8.08 – 8.14 (1H, m), 8.43 – 8.45 (1H, d), 9.08 – 9.13 (1H, d).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,77555-27-2, its application will become more common.
Reference:
Patent; TORRENT PHARMACEUTICALS LTD; WO2005/97746; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem