Related Products of 13626-17-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13626-17-0 as follows.
Intermediate 24: 2-(benzeuesulfonyl)-2-(5-bromo-4-chloropyridin-3-yl)acetonitrile To a stirred and nitrogen degassed solution of 2-{benzenesulfonyflacetonitrile (CM 7605-25-9; 7.64 g, 42.20 mmol) in anhydrous DME (100 mL) was added sodium hydride (3.83 g, 96 mmol, 6o% dispersion in oil) at o C. The mixture was stirred at oC for 5 mm and then at it for 15 mm. This mixture was added to a previously nitrogen degassed solution of 3,5-dibromo-4-chloropyfldane (CM 13626-17-0; 10.40 g, 38.30 mmol), tetrakis(triphenylphosphane) palladium (i.ii g, 958 jimol) in anhydrous DME (100 mL). The reaction mixture was heated at reflux for 16 h. The reaction mixture was partitioned between EtOAc and water. The organic phase was washed with brine, dried (MgSO4) and concentrated in vacuo. The crude product was purified by column chromatography (Ci8-silica, o-8o% acetonitrile / water (with o.i% ammonia)) to affordthe title compound. -?H NMR (400 MHz, DMSO-d6) 6 ppm 7.37 7.58 (m, 3 H) 7.67 – 7.83 (m, 3 H) 8.13 – 8.29 (m, 1 H) 8.31 – 8.44 (m, 1 H)MS ES: 372
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13626-17-0, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LTD; BARKER, Gregory; DAVENPORT, Richard; DOWNHAM, Robert; FARNABY, William; GOLDBY, Anne; HANNAH, Duncan; HARRISON, David; WILLEMS, Henriette; (390 pag.)WO2015/198045; (2015); A1;,
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