Reference of 902837-39-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.902837-39-2, name is 3-Bromo-5-iodopyridin-4-amine, molecular formula is C5H4BrIN2, molecular weight is 298.91, as common compound, the synthetic route is as follows.
8-Bromo-4-methyl-1,6-naphthyridin-2(1H)-one To a solution of 3-Bromo-5-iodopyridin-4-amine (1.5 g, 5.02 mmol) in DMF (12 mL) was added methyl crotonate (1.064 mL, 10.04 mmol), triethylamine (0.974 mL, 7.03 mmol), tri-o-tolylphosphine (0.12 g, 0.401 mmol) and palladium(II)acetate (0.045 g, 0.201 mmol) under nitrogen and the mixture was stirred at 120 C. for 48 h. The DMF was evaporated (V10 biotage system) and the resulting residue was purified by chromatography on silica gel (biotage, CH2Cl2/MeOH, 100:0 to 92:8) to give the product (0.82 g, 69%) as a red solid. This solid was further purified by recrystallization from hot EtOAc to give the pure product (503 mg, 42%) as a beige solid.
Statistics shows that 902837-39-2 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-iodopyridin-4-amine.
Reference:
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
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