Adding a certain compound to certain chemical reactions, such as: 1122-62-9, 1-(Pyridin-2-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1122-62-9, blongs to pyridine-derivatives compound. 1122-62-9
General procedure: To a 25 mL Schlenk tube containing a solution of 1 in 2 mL of THF was added an aldehyde (1.0 mmol) and (EtO)3 SiH (0.20 g, 1.2 mmol). The reaction mixture was stirred at 50-55 C until there was no aldehyde left (monitored by TLC and GC-MS). The reaction was then quenched byMeOH (2mL) and a 10% aqueous solution of NaOH (5 mL) with vigorous stirring at 60 C for about 24 h.The organic product was extracted with diethyl ether (10 mL ¡Á 3), dried over anhydrous MgSO4, and concentrated under vacuum. The alcohol product was further purified using flash column chromatography (elute with 5-10% ethyl acetate in petroleum ether). The 1H NMR and 13C NMR spectra of the alcohol products are providedin Supporting information.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-62-9, its application will become more common.
Reference:
Article; Xue, Benjing; Sun, Hongjian; Niu, Qingfen; Li, Xiaoyan; Fuhr, Olaf; Fenske, Dieter; Catalysis Communications; vol. 94; (2017); p. 23 – 28;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem