In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1000339-23-0, name is 2-Amino-5-bromoisonicotinic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C6H5BrN2O2
A mixture of compound 14-2 (7.81 g, 35.6 mmol), DPPA (9.40 mL, 43.5 mmol) and Et3N (5.90 mL, 42.5 mmol) in i-BuOH (300 mL) was stirred at 90 C for 6 hrs under an atmosphere of N2. The solvent was removed and the residue was purified by silica gel column chromatography (Petroleum ether/EtOAc = 5/1 to 4/1 (v/v)) to give compound 14-3 (4.9 g, 47% yield) as a white solid. LC-MS (ESI): m/z 234 [M-56+H]+.
The synthetic route of 1000339-23-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRESIDIO PHARMACEUTICALS, INC.; ZHONG, Min; LI, Leping; WO2012/58125; (2012); A1;,
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