Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 133081-25-1, name is 6-(2-(tert-Butoxycarbonyl)hydrazinyl)nicotinic acid. A new synthetic method of this compound is introduced below., Formula: C11H15N3O4
A mixture of 2-chloro-4,6-dimethyl-1,3,5-triazine (CDMT) (1.76 g, 10 mmol), 2 (2.53 g, 10 mmol) in THF (10 ml), and N-methylmorpholine (1.1 ml, 10 mmol) and after 4 h 4d (3.40 g, 10 mmol) in THF were combined as above to afford 5d as yellow solid. Compound 5d: mp 176-178 C; yield 36%; IR (KBr) nu (cm-1): 1522.7, 1636.0, 1719.2, 2853.6, 2926.7, 3251.6; 1H NMR (CD3OD) (delta ppm): 8.5 (1H, m, ArH), 8.3 (1H, d, J = 8.7 Hz, ArH), 8.0 (1H, m, ArH), 7.7 (1H, m, ArH), 7.6 (1H, m, ArH), 7.5 (1H, t, J = 5.3 Hz, ArH), 6.7 (1H, d, J = 8.9 Hz, CCHC), 4.6 (2H, s, NH), 3.9-4.0 (2H, m, NHCH2), 3.3 (3H, m, NH,CH2), 3.0 (2H, m, CH2), 2.7 (2H, m, CH2), 2.3 (1H, m, NH), 1.9 (4H, m, CH2), 1.8 (2H, m, CH2), 1.6 (4H, m, CH2), 1.3-1.4 (9H, s, BOC), 1.3 (8H, br, CH2); MS (FAB) m/z (M + 1) 575.4, 475.4, 197.1; MS-HR (FAB) Calcd for C33H46N6O3: 574.36314. Found: 575.36921 (M + 1).
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Reference:
Article; Szymanski, Pawel; Markowicz, Magdalena; Mikiciuk-Olasik, Elbieta; Bioorganic Chemistry; vol. 39; 4; (2011); p. 138 – 142;,
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