The synthetic route of 1156542-28-7 has been constantly updated, and we look forward to future research findings.
Synthetic Route of 1156542-28-7 , The common heterocyclic compound, 1156542-28-7, name is 5-Chloro-4-(trifluoromethyl)picolinonitrile, molecular formula is C7H2ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To 7 ml of ethanol were added 0.61 g of sodium bicarbonate and 0.5 g of hydroxylamine hydrochloride, and the mixture was heated to reflux for 1 hour. After allowing to cool, 0.74 g of 5-chloro-4-trifluoromethylpyridine-2-carbonitrile was added at O0C, and the mixture was stirred for 5 hours, and concentrated. To the residue was added water, the resultant solution was extracted with ethyl acetate three times, and the organic layers were combined, washed with an aqueous saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.6 g of 5-chloro-4- trifluoromethylpyridine-2-carboxamide=oxime. 5-Chloro-4-trifluoromethylpyridine-2-carboxamide=oxime1H-NMR (DMSO-d6): 6.02 (s, 2H), 8.14 (s, IH), 8.93 (s, IH), 10.31 (s, IH)
The synthetic route of 1156542-28-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/66786; (2009); A1;,
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