Related Products of 10177-32-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 10177-32-9 as follows.
MeI (0.2 mL, 3.00 mmol, 0.25 equiv) was added to a solution of methyl ester 14 (2 g, 12 mmol) in MeCN (16 mL), and the mixture was heated at 120 C under microwave conditions for 1 h. The solvent wasthen removed, and the oily residue was taken up in EtOAc, treated with charcoal, filtered, and re-concentrated to give 4-pyridinone 16 as a viscous oil that solidified to a near colourless solid on standing (2g, 95%). IR (ATR): 1645, 1717, 2950, 3013, 3053, 3094 cm-1. 1H NMR (CDCl3): delta = 8.12 (s, 1 H), 7.21-7.24 (dd, 3J = 7.7 Hz, 4J = 2.5 Hz,1 H), 6.44 (d, 3J = 7.5 Hz, 1 H), 3.83 (s, 3 H), 3.69 (s, 3 H). 13C NMR (CDCl3): delta = 174.8, 165.3, 146.6, 139.8, 122.7, 118.1, 51.9,44.9. HRMS (HESI): m/z [M + H]+ calcd for C8H9NO3: 168.0655; found:168.0657.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10177-32-9, its application will become more common.
Reference:
Article; Koperniku, Ana; Zamiri, Maryam; Grierson, David S.; Synthesis; vol. 51; 8; (2019); p. 1779 – 1790;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem