Synthetic Route of 623942-84-7 ,Some common heterocyclic compound, 623942-84-7, molecular formula is C7H8BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of (3-bromo-6-methoxypyridin-2-yl)methanol (1.9 g, 8.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (1.8 g, 10 mmol) and triphenylphosphine (2.6 g, 10 mmol) under an ice bath condition and nitrogen atmosphere. The reaction mixture was stirred at rt for 3 h and then concentrated in vacuo, the residue was purified by column chromatography on a silica gel eluted with PE/EA (v/v = 30/1) to give the title compound as light yellow liquid (1.4 g, 57 %).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623942-84-7, its application will become more common.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; WANG, Xiaojun; YANG, Xinye; WU, Junwen; XIONG, Shaohui; PAN, Shengqiang; CAO, Shengtian; ZHANG, Yingjun; (121 pag.)WO2018/24224; (2018); A1;,
Pyridine – Wikipedia,
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