Synthetic Route of 1558302-68-3, Adding some certain compound to certain chemical reactions, such as: 1558302-68-3, name is 6-Chloro-1-methyl-1H-pyrazolo[4,3-c]pyridine,molecular formula is C7H6ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1558302-68-3.
A mixture of 6-chloro-l-methyl-lH-pyrazolo[4,3-c]pyridine (140 mg, 0.84 mmol), l-(3,4-dihydroisoquinolin-2(lH)-yl)-3-(3-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenoxy)propan-2-ol (512 mg, 1.25 mmol), Pd(dppf)Cl2 (61 mg, 0.084 mmol) and K2C03 (348 mg, 2.52 mmol) in dioxane and H20 was stirred under N2 atmosphere at 100C overnight. After cooling, the mixture was extracted with DCM, the combined organic layers dried over Na2S04 and concentrated to give the crude material which was purified by prep- HPLC to afford the title compound as the formate salt (42 mg, Yield 12%). 1H NMR (400 MHz, MeOD): delta 9.09 (s, 1H), 8.24 (s, 1H), 7.96 (s, 1H), 7.65-7.61 (m, 2H), 7.44-7.41 (m, 1H), 7.27-7.16 (m, 4H), 7.07-7.04 (m, 1H), 4.37-4.32 (m, 1H), 4.38 (s, 2H), 4.16 (d, J = 4.8 Hz, 2H), 4.13 (s, 3H), 3.52-3.53 (m, 2H), 3.31-3.30 (m, 2H), 3.30-3.29 (m, 2H), 2.65 (s, lH)ppm; ESI-MS (m/z): 415.2 [M+l] +.
According to the analysis of related databases, 1558302-68-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100695; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem