The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1079054-78-6, name is 5-Amino-6-methylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1079054-78-6
Step B: 5-chloro-6-methylpicolinonitrile (3)A solution of 5-amino-6-methylpicolinonitrile (2) (260 mg, 1.95 mmol), CuCl (290 mg, 2.93 mmol) and t-BuONO ( 456 mg, 3.9 mmol) in CH3CN (10 mL) was stirred at room temperature under 2 for 2 h, and then warmed to 60C. After 2h, 10 mL 6N HCl was added and extracted with EA (3×10 mL). The organic phase was dried with anhydrous Na2S04, filtered and concentrated. The residue was purified by Prep-TLC using PE/ EtOAc = 1/1 to give title compound as oil.
With the rapid development of chemical substances, we look forward to future research findings about 1079054-78-6.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; MCCOMAS, Casey, C.; REGER, Thoma, S.; QI, Changhe; WO2014/150114; (2014); A1;,
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