Introduction of a new synthetic route about Ethyl 4-chloropicolinate

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64064-56-8, Ethyl 4-chloropicolinate, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.64064-56-8, name is Ethyl 4-chloropicolinate, molecular formula is C8H8ClNO2, molecular weight is 185.61, as common compound, the synthetic route is as follows.Computed Properties of C8H8ClNO2

Example 4 (4-chloro-pyridin-2-yl)-methanol To a solution of ethyl 4-chloropicolinate (11.14 g, 60 mmol) in abs. ethanol (450 ml) was added, with stirring at 0 C., sodium borohydride (3.63 g, 96 mmol). The mixture was stirred at for one hour, and another 30 minutes at room temperature. After heating to 70 C. for one hour, water was added cautiously at room temperature. The pH-value was adjusted to 5.5 with aqueous HCl (4M). After stirring for 14 hours, the volatiles were removed in vacuo. Water was added, and the mixture was extracted with dichloromethane (2*200 ml each). The organic phase was dried over sodium sulfate, filtered, and evaporated to yield (4-chloro-pyridin-2-yl)-methanol as a clear yellow oil. C6H6ClNO, Fw 143.57. 1H NMR (360 MHz, CDCl3): delta=8.33 (d, J=5.4 Hz, 1H); 7.28 (d, J=1.6 Hz, 1H); 7.12 (dd, J=5.4, 1.6 Hz, 1H); 4.66 (s, 2H); 3.98 (br s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,64064-56-8, Ethyl 4-chloropicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Schlingloff, Gunther; Nivalkar, Kishor Ramachandra; Wieprecht, Torsten; Dubs, Marie-Josee; End, Nicole; US2009/44345; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem