As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 884494-51-3, name is 2-Fluoro-4-iodonicotinic acid, molecular formula is C6H3FINO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Fluoro-4-iodonicotinic acid
To a solution of 401-C (10.3 g, 38.6 mmol) in 40 mL of MeOH and Et2O (40 mL) cooled with ice-water, TMSCH2N2(29 mL, 57.9 mmol) was added dropwise. The mixture was stirred at 25 C for overnight. Then ice water was added toquench the reaction. The solvent was removed by evaporation and Sat. NaHCO3 was added and the mixture was stirredfor 30 minutes. The mixture was extracted with EtOAc (100 mL3). The combined organic phase was washed with brine,dried over Na2SO4, filtered and concentrated to dry to give product 401-D (methyl 2-fluoro-4-iodonicotinate, 9.6 g, yield:88%).1H NMR (300 MHz, DMSO-d6): delta 8.06 (d, J = 5.4 Hz, 1H), 7.97 (d, J = 5.1 Hz, 1H), 3.93 (s, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 884494-51-3.
Reference:
Patent; Kangpu Biopharmaceuticals, Ltd.; LEE, Wen-Cherng; LIAO, Baisong; ZHANG, Lei; EP3590924; (2020); A1;,
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