Adding a certain compound to certain chemical reactions, such as: 1314353-68-8, 5-Cyclopropylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 5-Cyclopropylpyridin-3-amine, blongs to pyridine-derivatives compound. Quality Control of 5-Cyclopropylpyridin-3-amine
At 0 C, to a solution of 5-cyclopropylpyridin-3-amine (2.08 g, 15.49 minol) in tetrahydrofuran (30 mL) was added a solution of NaHMDS (6.84 g, 37.30 minol) in tetrahydrofuran (20 mL) dropwise over 10 min period. The resulting solution was stirred for 1 h at 0 C, and then was added by a solution of di-tert-butyl dicarbonate (4.85 g, 22.20 minol) in tetrahydrofuran (25 mL) dropwise. The resultingminxture was stirred for additional 2 h at room temperature. When the reaction was done, it was quenched by the addition of sat. NH4C1 solution (100 mL). The resultingminxture was extracted with ethyl acetate (100 mL x 3). The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with MeOH in EtOAc (0% to 80% gradient) to yield tert-butyl N-(5- cyclopropylpyridin-3-yl)carbamate as white solid (2.52 g, 69%). MS: m/z = 235.0 [M+Hj.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1314353-68-8, 5-Cyclopropylpyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian A.; BRUGGER, Nadia; (546 pag.)WO2017/106607; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem