The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14432-12-3, name is 4-Amino-2-chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H5ClN2
To a ice-cooled solution of 4-amino-2-chloro-pyridine (8.09g, 63 mmol, 1eq) in water [(150ML)] was added concentrated 98% HCl whilst maintaining the reaction at [0C A] solution of sodium nitrite (5.65g, [82MMOL,] 1.3eq) in water [(50ML)] was added slowly [AT-10C.] The mixture was stirred at-10C [FOR 40 MIN] and a solution of potassium iodide (12.55g, 75. [6MMOL,] 1.2eq) in water [(50ML)] was added. The resulting mixture was stirred at [0C] overnight. After treatment with [NAOH] 35%, and extraction with ethyl acetate, the organic phases were combined and dried over [NA2SO4.] The solvent was removed under reduced pressure and the residue was purified by chromatography on silica gel (eluent : CH2CI2 then [CH2CL2/CH30H] 99/1) to give the title compound as an orange solid (9.5g, 63%) ;’H NMR (300 MHz, CDCl3) [6] : 7.99 (d, [1H),] 7.68 (s, 1H), 7.52 (d, 1H) ; (GC-MS) m/z: 239.
With the rapid development of chemical substances, we look forward to future research findings about 14432-12-3.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/13125; (2004); A1;,
Pyridine – Wikipedia,
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