In 2022,Wu, Gaorong; Xu, Xiaobo; Wang, Shuai; Chen, Lu; Pang, Binghan; Ma, Tao; Ji, Yafei published an article in Chinese Chemical Letters. The title of the article was 《Metal-free directed C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines》.Recommanded Product: 2-Bromo-5-methylpyridine The author mentioned the following in the article:
A novel method for metal-free C-H pyridine-directed borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines with BBr3 has been reported, affording complexes R1C6H3(Bpin)-2-XR2-5-FC5H4N-2 (X = N, CH; R1 = H, alkyl, halo; R2 = H, Me). The 5-fluoropyridine directed borylation reaction exhibited high efficiency and site exclusivity. The useful protocol could be executed on a gram-scale easily and the borylated products showed good derivatization applications. Moreover, the practicality of the strategy was expanded by the fact that the directing group could be removed in an acceptable yield. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2-Bromo-5-methylpyridine