In 2022,Liu, Hao; Chi, Wei; Lin, Meng-Ling; Dong, Lin published an article in Organic Chemistry Frontiers. The title of the article was 《Iridium(III)-catalyzed two-fold C-H alkylation of BINOLs with allyl alcohols》.Synthetic Route of C6H6BrN The author mentioned the following in the article:
Ir(III)-Catalyzed C-H alkylation of BINOL units I (R1 = H, Me, MeO, Br; R2 = H, Me, Ph, etc.; R3 = pyridin-2-yl, 3-methoxypyridin-2-yl, thiazol-2-yl, etc.; R4 = Me, pyridin-2-yl, 3-methoxypyridin-2-yl, etc.) has been well examined by using allyl alcs. CH2=CHCH(R5)OH (R5 = Et, benzyl, thiophen-2-yl, etc.) as coupling partners. Under the advantage of the pyridine guiding group, the efficient protocol allows the rapid synthesis of diverse BINOL carbonyl compounds II and III with the retention of optical purity. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Synthetic Route of C6H6BrN) was used in this study.
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Synthetic Route of C6H6BrN