Shuman, Robert T. published the artcileAn improved synthesis of homoproline and derivatives, Synthetic Route of 123811-75-6, the main research area is homoproline derivative; proline homo derivative; piperidinecarboxylic acid; benzohomoproline.
Homoproline derivatives I (R = 3-Me, 4-Me, 6-Me, 4-Et, 4-OMe, 4-CMe3) were prepared from the corresponding pyridines II in 4 steps. A key step was the treatment of N-oxides III (R = same) with Me3SiCN and Me2NCOCl in CH2Cl2 to give nitriles IV (R = same). 5,6-Benzohomoprolines V (R1 = H, Me) were also prepared
Journal of Organic Chemistry published new progress about homoproline derivative; proline homo derivative; piperidinecarboxylic acid; benzohomoproline. 123811-75-6 belongs to class pyridine-derivatives, name is 4-(tert-Butyl)picolinic acid hydrochloride, and the molecular formula is C10H14ClNO2, Synthetic Route of 123811-75-6.