Vrijdag, Johannes L. published the artcileTowards New Tricyclic Motifs: Intramolecular C-H Arylation as the Key Step in a Formal [3+3] Cyclocondensation Strategy, Category: pyridine-derivatives, the publication is European Journal of Organic Chemistry (2017), 2017(11), 1465-1474, database is CAplus.
Tricyclic scaffolds structurally related to the well-known benzodiazepine class of drugs show diverse biol. activities strikingly different from those of their benzodiazepine counterparts. Interested by this scaffold-hopping perspective, we previously developed a continuous-flow method for the conversion of benzodiazepinediones into oxazoloquinolinones. Attempted extension of this synthetic route to the corresponding oxazolonaphthyridinone scaffolds met with limited success, however. This encouraged us to develop a different approach to pyridine-based tricyclic motifs. In line with our interest in scaffold hopping, in this paper authors describe a general, convergent [3+3] cyclocondensation approach to [1,3]oxazolo[4,5-c]-1-naphthyridin-4(5H)-ones. The key synthetic steps in this approach are: (1) the construction of an amide linkage connecting two peripheral heterocycles; and (2) a palladium-catalyzed intramol. C-H arylation to complete the tricyclic scaffold.
European Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C8H10O2, Category: pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem