Barlaam, Bernard published the artcileNew heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors, COA of Formula: C6H7ClN2O, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(24), 5446-5449, database is CAplus and MEDLINE.
A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthesized and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and phys. properties suitable for oral dosing were achieved within this series: I [X = CH, N] were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.
Bioorganic & Medicinal Chemistry Letters published new progress about 742070-73-1. 742070-73-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Amine,Ether, name is 2-Amino-3-chloro-6-methoxypyridine, and the molecular formula is C6H7ClN2O, COA of Formula: C6H7ClN2O.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem