Chen, Meng-Hsin published the artcileSynthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors, Quality Control of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 2222-2226, database is CAplus and MEDLINE.
Synthesis and biol. activities of some quinolinone and dihydroquinolinone p38 MAP kinase inhibitors are reported. Modifications to the dihydroquinolinone pharmacophore revealed that dihydroquinolinone may be replaced with a quinolinone pharmacophore and lead to enhanced p38 inhibitory activity. From a study of C-7 substitutions by amino acid side chains, a very potent series of compounds, e.g., I, in the p38 enzyme assays was identified. Translation of the in vitro activity into reasonable whole blood activity can be improved in this series of compounds by judicious modification of the phys. properties at appropriate regions of the lead.
Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Quality Control of 197958-29-5.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem