Hansen, Marvin M. published the artcileBoronic Acids and Derivatives-Probing the Structure-Activity Relationships for Mutagenicity, Computed Properties of 197958-29-5, the publication is Organic Process Research & Development (2015), 19(11), 1507-1516, database is CAplus.
Despite a recent publication describing boronic acids as a “novel class of bacterial mutagen,” process and anal. chemists may not be aware of the potential worker exposure hazards, or of the need to assess boron compounds as potential genotoxic impurities (GTIs) per ICH M7. This publication provides new Ames data for 44 com. available boronic acids, boronic acid derivatives, and boron-containing reagents. Trends in the Ames data are discussed from a structure-activity perspective. Common reagents such as bis(pinacolato)diboron and bis-boronic acid were shown to be mutagenic in the Ames assay. Currently available in silico computational models were found to provide little value in predicting the outcome of the Ames assay for boronic acids and derivatives The authors propose oxygen-mediated oxidation of boron compounds to generate organic radicals as a potential mechanism for mutagenicity. It is hoped that this paper will result in increased awareness of this class of GTIs and prompt publication of addnl. Ames data for boronic acids and their derivatives that will lead to improved (Q)SAR models and an understanding of the mechanism of mutagenicity.
Organic Process Research & Development published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Computed Properties of 197958-29-5.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem