Frischmuth, Annette published the artcilePreparation of Functionalized Indoles and Azaindoles by the Intramolecular Copper-Mediated Carbomagnesiation of Ynamides, SDS of cas: 39856-58-1, the publication is Angewandte Chemie, International Edition (2013), 52(38), 10084-10088, database is CAplus and MEDLINE.
The authors report a mild and general one-pot preparation of indoles and azaindoles using a 5-endo-dig copper-mediated intramol. carbometalation of magnesiated derivatives, which lead to cuprated intermediates that, after quenching with various electrophiles, afford functionalized N-heterocycles. Thus, 2-bromo-4-fluoroaniline reacted with PhSO2Cl to give the N-phenylsulfonyl derivative, which was alkynylated with phenyl[(trimethylsilyl)ethynyl]iodonium triflate to give alkyne derivative I (R = F, CF3, CN, CO2CMe3). I was then treated with iso-PrMgCl·LiCl to give the Mg reagents that were cyclized with electrophiles using a catalytic amount of CuCN·2LiCl to produce the corresponding indoles II [R1 = CH2C(CO2Et):CH2, COC6H4Cl-3, cyclopropylcarbonyl, 2-cyclohexenyl, COC6H4Me-4] in 62-93% yield.
Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, SDS of cas: 39856-58-1.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem