Steinig, Arno G. published the artcileNovel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases, Application In Synthesis of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(15), 4381-4387, database is CAplus and MEDLINE.
A series of novel 6-aminofuro[3,2-c]pyridines as kinase inhibitors is described, most notably, OSI-296. We discuss our exploration of structure-activity relationships and optimization leading to OSI-296 and disclose its pharmacol. activity against cMET and RON in cellular assays. OSI-296 is a potent and selective inhibitor of cMET and RON kinases that shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated.
Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C10H9NO, Application In Synthesis of 197958-29-5.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem