Lodagekar, Anurag published the artcileCo amorphous valsartan nifedipine system: Preparation, characterization, in vitro and in vivo evaluation, Computed Properties of 21829-25-4, the main research area is valsartan nifedipine amorphous system stability hydrogen bonding; Bioavailability; Co-amorphous delivery system; Dissolution; Nifedipine; Pharmacokinetic; Valsartan.
Co amorphous systems are supersaturated drug delivery systems which offer a basic platform for delivery of multicomponent adducts (combination of more than one active pharmaceutical ingredient (API)) and/or as a fixed dose combination therapy, in addition to their potential to improve the apparent solubility, dissolution rate and ultimately bioavailability of poorly water soluble APIs. In the present work, a new drug-drug co amorphous system namely valsartan-nifedipine was prepared by quench cooling technique. Prepared co amorphous system was characterized for its solid state behavior with the help of Fourier Transform IR spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Powder X Ray Diffractometry (PXRD). The optimized co amorphous system was stable for 1 mo when exposed to accelerated stability condition (40 ± 2°C and 75 ± 5% RH). The improved stability of amorphous nifedipine in co amorphous system was attributed to improved miscibility and intra and intermol. non-covalent interactions mainly due to presence of hydrogen bonding between valsartan and nifedipine which was studied by FTIR anal. Co amorphous systems were evaluated by mainly in vitro dissolution and in vivo benefit. In vitro dissolution study showed nearly 5.66 folds and 1.61 folds improvement which was translated to 3.63 and 2.19 times enhancement in vivo Cmax for nifedipine and valsartan resp.
European Journal of Pharmaceutical Sciences published new progress about Amorphous films. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Computed Properties of 21829-25-4.