Pajzderska, A. published the artcileNMR relaxometry in an investigation of the kinetics of the recrystallization of a three-phase system, SDS of cas: 72509-76-3, the main research area is polyvinylpyrrolidone nuclear magnetic resonances relaxometry recrystallization three phase system; Amorphization; Felodipine; PVP; Physical mixture; Recrystallization; Relaxometry.
The method of 1H NMR (NMR) relaxometry is applied to investigate the kinetics of the recrystallization of an active pharmaceutical ingredient (felodipine) from the amorphous phase of its phys. mixture with a polymer (polyvinylpyrrolidone, PVP). Comparison of the recrystallization results obtained for amorphous felodipine and its mixtures with PVP shows that the recrystallization process of API is faster in the mixtures and depends on the content of water in the system. The free induction decay (FID) for protons that were detected are composed of three components, and the loss of water from PVP strongly influences the part characterized by the longest spin-spin lattice relaxation time. Anal. of the FID of the phys. mixture indicates that the content of water does not change during the recrystalization process. The study shows that the T11H NMR relaxometry method is very useful for analyzing the composition of a three-phase mixture and the recrystallization process.
International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Amorphization. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, SDS of cas: 72509-76-3.