Application of 5-Bromo-2-chloro-3-nitropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67443-38-3, 5-Bromo-2-chloro-3-nitropyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.COA of Formula: C5H2BrClN2O2

General procedure: A mixture of 5-Bromo-2chloro-3-nitropyridine (2) (10mmol), organicamine compound (14mmol), and N,N-diisopropylethylamine (30mmol) in 1,4-dioxane (100mL) was stirred at room temperature for 4h. After the reaction was completed by TLC analysis, the volatiles were removed under reduced pressure. The mixture was extracted with CH2Cl2 (3¡Á60mL) and washed with H2O (3¡Á60mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo.The resulting residue was purified by column chromatography on silica gel (PE: EA=9:1) to obtain theintermediates 3a-j.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67443-38-3, 5-Bromo-2-chloro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Article; Du, Shan; Li, Wei-Ya; Liu, Wen-Shan; Ma, Yang-Chun; Ma, Ying; Wang, Rui-Rui; Wang, Run-Ling; Yang, Bing; Zhou, Liang; Bioorganic Chemistry; vol. 100; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem