Related Products of 1021339-19-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1021339-19-4 as follows.
step 1 : To a solution of 6-chloro-lH-pyrrolo[3,2-b]pyridine (5.0 g, 32.8 mmol) in THF (150 mL) in an ice bath was added NaH (1.57 g, 60% in mineral oil, 39.3 mmol). After stirring in an ice bath for 30 min, 4-toluenesulfonyl chloride (6.87 g, 36.1 mmol) was added. The mixture was stirred at RT overnight. The reaction mixture was quenched with water (50 mL) at 0 C and extracted with EtOAc (300 mL). The extract was dried (Na2S04), filtered, and concentrated under reduced pressure. The crude product was purified by S1O2 chromatography eluting with petroleum ether/EtOAc gradient (8:1 to 2:1) to afford 6- chloro-l -tosyl-lH-pyrrolo[3,2-b]pyridine as a yellow solid (8.5 g, 84%). MS (ESI): m/z = 307.0 [M+l]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1021339-19-4, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy; WO2013/92940; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem