Visible-Light-Activated Asymmetric Addition of Hydrocarbons to Pyridine-Based Ketones was written by Yu, Han;Zhan, Tangyu;Zhou, Yuqiao;Chen, Long;Liu, Xiaohua;Feng, Xiaoming. And the article was included in ACS Catalysis in 2022.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:
A combined system involving Er(III)-based chiral Lewis acid catalysis, Ir(III)-based photoredox catalysis, and bromide-radical-mediated hydrogen atom transfer was disclosed. The introduction of a bulky and nonredox chiral Lewis acid through the photoredox pathway enabled the radical addition process and inhibited the above competitive reactions. The visible-light-promoted catalytic asym. alkylation of heteroaryl-based ketones with diverse hydrocarbons (mainly benzyl) delivered a variety of congested enantioenriched tertiary alcs. (up to 97% yield, 96% enantiomeric excess (ee)). In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: Phenyl(pyridin-2-yl)methanone