Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation was written by Wagener, Tobias;Heusler, Arne;Nairoukh, Zackaria;Bergander, Klaus;Daniliuc, Constantin G.;Glorius, Frank. And the article was included in ACS Catalysis in 2020.Safety of 3-Fluoro-4-methylpyridine This article mentions the following:
Fluorinated piperidines are desirable motifs for pharmaceutical and agrochem. research. Nevertheless, general synthetic access remains out of reach. Herein, we describe a simple and robust cis-selective hydrogenation of abundant and cheap fluoropyridines to yield a broad scope of (multi)fluorinated piperidines. This protocol enables the chemoselective reduction of fluoropyridines while tolerating other (hetero)aromatic systems using a com. available heterogeneous catalyst. Fluorinated derivatives of important drug compounds are prepared, and a straightforward strategy for the synthesis of enantioenriched fluorinated piperidines is disclosed. In the experiment, the researchers used many compounds, for example, 3-Fluoro-4-methylpyridine (cas: 399-88-2Safety of 3-Fluoro-4-methylpyridine).
3-Fluoro-4-methylpyridine (cas: 399-88-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Safety of 3-Fluoro-4-methylpyridine