A Convenient Esterification of N-Heteroarene Methanols via C-CN Bond Cleavage of Benzoyl Cyanides as Acylating Sources was written by Su, Fangyao;Zhao, Qianrui;Wang, Mengzhuo;Zhao, Mingzhang;Ren, Yihe;Zhu, Binghan;Chen, Haoran;Lai, Miao;Zhao, Mingqin. And the article was included in ChemistrySelect in 2022.Product Details of 131747-45-0 This article mentions the following:
An efficient and straightforward methodol. for the esterification of various N-heteroarene methanols using benzoyl cyanides as acylating sources through a simply mixing conditions has been reported. The acyl groups were in-situ generated via chemoselective C-CN bond cleavage to give the N-heteroarenemethyl esters. This process features in readily accessible starting materials and offers an easy operational procedure, and broad substrate scope with excellent selectivity. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Product Details of 131747-45-0).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâ? in pyridine vs. 150 kJ·molâ? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one CâH in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 131747-45-0