Kalindjian, S. Barret et al. published their research in Journal of Medicinal Chemistry in 2016 | CAS: 76005-99-7

2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 76005-99-7

A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease was written by Kalindjian, S. Barret;Kadnur, Sanjay V.;Hewson, Christopher A.;Venkateshappa, Chandregowda;Juluri, Suresh;Kristam, Rajendra;Kulkarni, Bheemashankar;Mohammed, Zainuddin;Saxena, Rohit;Viswanadhan, Vellarkad N.;Aiyar, Jayashree;McVey, Donna. And the article was included in Journal of Medicinal Chemistry in 2016.Reference of 76005-99-7 This article mentions the following:

Chemokine receptor 9 (CCR9), a cell surface chemokine receptor which belongs to the G protein-coupled receptor, 7-trans-membrane superfamily, is expressed on lymphocytes in the circulation and is the key chemokine receptor that enables these cells to target the intestine. It has been proposed that CCR9 antagonism represents a means to prevent the aberrant immune response of inflammatory bowel disease in a localized and disease specific manner and one which is accessible to small mol. approaches. One possible reason why clin. studies with vercirnon, a prototype CCR9 antagonist, were not successful may be due to a relatively poor pharmacokinetic (PK) profile for the mol. We wish to describe work aimed at producing new, orally active CCR9 antagonists based on the 1,3-dioxoisoindoline skeleton. This study led to a number of compounds that were potent in the nanomolar range and which, on optimization, resulted in several possible preclin. development candidates with excellent PK properties. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7Reference of 76005-99-7).

2-Methoxy-4-methylpyridin-3-amine (cas: 76005-99-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol� in pyridine vs. 150 kJ·mol� in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 76005-99-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem