Ruthenium-catalyzed C-H allylation of arenes with allylic amines was written by Yan, Rui;Wang, Zhong-Xia. And the article was included in Organic & Biomolecular Chemistry in 2018.Synthetic Route of C12H11N This article mentions the following:
The Ru-catalyzed pyridyl-directed C-H allylation of arenes with allylic amines was developed. This reaction was carried out in the presence of 5 mol% of [Ru(p-cymene)Cl2]2 and 0.5 equivalent of AgOAc in CF3CH2OH at 75°, afforded the allylated products of arenes in moderate to excellent yields. The method exhibited a wide scope of allylic amines and arenes and showed a good compatibility of functional groups. The pyrazolyl- and pyrimidyl-directed C-H allylation of arenes were also performed under the same conditions. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C12H11N