Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists was written by Simeone, Joseph P.;Bugianesi, Robert L.;Ponpipom, Mitree M.;Yang, Yi Tien;Lo, Jane-Ling;Yudkovitz, Joel B.;Cui, Jisong;Mount, George R.;Ren, Rena Ning;Creighton, Mellissa;Mao, An-Hua;Vincent, Stella H.;Cheng, Kang;Goulet, Mark T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Category: pyridine-derivatives This article mentions the following:
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Category: pyridine-derivatives).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives