Catalytic C-H Bond Addition of Pyridines to Allenes by a Rare-Earth Catalyst was written by Song, Guoyong;Wang, Baoli;Nishiura, Masayoshi;Hou, Zhaomin. And the article was included in Chemistry – A European Journal in 2015.Quality Control of 2-Isopropylpyridine This article mentions the following:
The catalytic C-H addition of pyridines to allenes was achieved for the first time by using a half-sandwich scandium catalyst, thus constituted a straightforward and atom-economical route for the synthesis of alkenylated pyridines. The reaction proceeded regio- and stereoselectively, affording a new family of alkenylated pyridines which were otherwise difficult to synthesize. A cationic Sc-η2-pyridyl species was isolated and confirmed to be a key catalyst species in the transformation. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Quality Control of 2-Isopropylpyridine).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 2-Isopropylpyridine