Aminoalkoxide-Mediated Formation and Stabilization of Phenylpyridyllithium: Straightforward Access to Phenylpyridine Derivatives was written by Gros, Philippe;Fort, Yves. And the article was included in Journal of Organic Chemistry in 2003.Formula: C11H8BrN This article mentions the following:
This work has revealed that lithium aggregates promoted the efficient metalation of phenylpyridines and stabilization of phenylpyridyllithium. The BuLi-LiDMAE superbase prevented dimerization or nucleophilic addition encountered with t-BuLi or n-BuLi. The reported selective pyridine ring lithiation of 2-, 3-, and 4-phenylpyridine α to nitrogen opens a straightforward access to their derivatives In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Formula: C11H8BrN).
2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C11H8BrN