Synthesis and biological activity of thiazolidine piperidine nicotinamide compounds was written by Ding, Chengrong;Pan, Yayun;Yin, Xu;Tan, Chengxia. And the article was included in Youji Huaxue in 2019.Name: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate This article mentions the following:
The structure of thiazolidine piperidine could affect the metabolic activities of cholesterol compounds in vivo, and it is the key pharmacophore of oxythiazolidine to inhibit the oxygen cholesterol-binding protein (OSBP) of pathogenic bacteria. 14 Novel thiazolidine piperidine nicotinamide derivatives were designed and synthesized in search of new bioactive compounds containing thiazolidine piperidine structure. The structures of target compounds were characterized by 1H NMR, 13C NMR and HRMS spectra. The preliminary bioassay showed that the target compounds generally had antibacterial activities. At the concentration of 100μg/mL, the antibacterial activity of one compound against Fusarium graminearum was 60%, the antibacterial activities of three compounds against Botrytis cinerea were 60%, the bacteriostatical activities of six compounds against Diplocarpon mali were 70%, and the antibacterial activity of(4-(5-(2,3-dichlorophenyl)-4-methylthiazol-2-yl)piperidin-1-yl)(5,6-dichloropyridin-3-yl)methanone (6k) against Phytophthora infestans (Mont.) de Bary was 75%. Therefore it was worth for further research about structural optimization. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Name: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate).
tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: tert-Butyl 4-carbamothioylpiperidine-1-carboxylate