Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties was written by Kuduk, Scott D.;Skudlarek, Jason W.;DiMarco, Christina N.;Bruno, Joseph G.;Pausch, Mark H.;O’Brien, Julie A.;Cabalu, Tamara D.;Stevens, Joanne;Brunner, Joseph;Tannenbaum, Pamela L.;Garson, Susan L.;Savitz, Alan T.;Harrell, Charles M.;Gotter, Anthony L.;Winrow, Christopher J.;Renger, John J.;Coleman, Paul J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Quality Control of 2-Fluoroisonicotinonitrile This article mentions the following:
Antagonism of orexin receptors has shown clin. efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, mols. related to the dual orexin receptor antagonist filorexant were transformed into compounds that were selective for the OX2R subtype. Judicious selection of the substituents on the pyridine ring and benzamide groups led to I; which was highly potent, OX2R selective, and exhibited excellent development properties. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Quality Control of 2-Fluoroisonicotinonitrile).
2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of 2-Fluoroisonicotinonitrile