Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile was written by Tamura, Yuusuke;Hayashi, Kyouhei;Omori, Naoki;Nishiura, Yuji;Watanabe, Kana;Tanaka, Nobuyuki;Fujioka, Masahiko;Kouyama, Naoki;Yukimasa, Akira;Tanaka, Yukari;Chiba, Takeshi;Tanioka, Hideki;Nambu, Hirohide;Yukioka, Hideo;Sato, Hiroki;Okuno, Takayuki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Computed Properties of C11H9NO This article mentions the following:
Optimization of HTS hit 1 (I) for NPY Y5 receptor binding affinity, CYP450 inhibition, solubility and metabolic stability led to the identification of some orally available oxygen-linker derivatives for in vivo study. Among them, derivative 4i inhibited food intake induced by the NPY Y5 selective agonist, and chronic oral administration of 4i in DIO mice caused a dose-dependent reduction of body weight gain. In the experiment, the researchers used many compounds, for example, 5-Phenylpyridin-2-ol (cas: 76053-45-7Computed Properties of C11H9NO).
5-Phenylpyridin-2-ol (cas: 76053-45-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâ? in pyridine vs. 150 kJ·molâ? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C11H9NO