Ligand Control in Selective C-H Oxidative Functionalization Using Pd-PEPPSI-Type Complexes was written by Bolbat, Ekaterina;Wendt, Ola F.. And the article was included in European Journal of Organic Chemistry in 2016.Related Products of 644-98-4 This article mentions the following:
To achieve high selectivity in directed C-H activation, an NHC ligand was introduced to a palladium catalyst. A range of Pd-PEPPSI complexes were applied in the direct acetoxylation of 2-phenylpyridine. The best catalyst is the one based on a diisopropylphenyl-substituted NHC ligand, and this was successfully used for the functionalization of sp2 as well as more challenging sp3 bonds for a broad variety of substrates. The explored method showed a highly improved selectivity compared to previously reported results with up to 96% yield for the monoacetoxylated product. Kinetic studies show that sterics of the catalyst is less important in dictating conversion and selectivity; despite an induction period, the catalyst is mol. in nature. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 644-98-4