Metal-Free Catalyzed Synthesis of Fluorescent Indolizine Derivatives was written by Yuan, Yu-Chang;Liu, Tian-Zhen;Zhao, Bao-Xiang. And the article was included in Journal of Organic Chemistry in 2021.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:
A mild and high efficient method to prepare indolizines such as I [R = H, Me; R1 = Me, Ph, CH2CH2CO2Et; R2 = H, Me, OEt; R3 = Me, Ph, 4-ClC6H4; R1R2 = (CH2)3] by two-component reaction with the acid as the catalyst was developed. In this reaction, a new ring efficiently formed in one-step reaction. A wide range of substrates could be applied and the desired products were obtained in 8-95% yields under metal-free conditions. Different indolizine derivatives I were synthesized by general conditions and microwave irradiation conditions, and compound I [R = H, R1 = Me, R2 = H, R3 = Ph] gave the best results with an isolated yield of 95% and 82%, resp. The structures of synthesized compounds I were characterized by spectral anal., and compound I [R = H, R1R2 = (CH2)3, R3 = 4-ClC6H4] was confirmed by single crystal X-ray anal. UV-vis absorption and fluorescence properties of these compounds I were correlated with substituent groups on indolizine rings. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of â?8.7 à 10â? cm3·molâ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâ? in the liquid phase and 140.4 kJ·molâ? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one CâH in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: Phenyl(pyridin-2-yl)methanone