Azomethines containing electron-attracting substituents. V. (2 + 4) Cycloaddition of p-tosylisonitrosomalonodinitrile. Scope and mechanism of the reaction was written by Fleury, Jean Pierre;Desbois, Michel;See, Jacqueline. And the article was included in Bulletin de la Societe Chimique de France in 1978.COA of Formula: C7H6N2 This article mentions the following:
Tetrahydropyridines I (R = H; R1 = H, Me, Ph; R2-R4 = H, Me) were obtained by treating 4-MeC6H4SO3N:C(CN)2 with R1CH:CR2CR3:CHR4 under reflux; C6H6 thermolysis of I in EtOH gave the pyridines II. I (R = R1 = R3 = Me, R2 = R4 = H) was similarly prepared The azabicyclooctenes III (R5 = 4-MeC6H4SO2, 4-O2NC6H4CO, Bz) were similarly obtained from 1,3-cyclohexadiene and RON:C(CN)2. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4COA of Formula: C7H6N2).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C7H6N2